(2001). Family Covenants and Genetic Testing: Utilizing the Skills Of Counseling Professionals in Implementing Family Covenants. The American Journal of Bioethics: Vol. 1, No. 3, pp. 1-2.

Hastings Center Report, Volume 52, Issue S1, Page S3-S11, March‐April 2022.

Adaptive mutation is defined as a process that, during nonlethal selections, produces mutations that relieve the selective pressure whether or not other, nonselected mutations are also produced. Examples of adaptive mutation or related phenomena have been reported in bacteria and yeast but not yet outside of microorganisms. A decade of research on adaptive mutation has revealed mechanisms that may increase mutation rates under adverse conditions. This article focuses on mechanisms that produce adaptive mutations in one strain of Escherichia coli, FC40. (...) These mechanisms include recombination-induced DNA replication, the placement of genes on a conjugal plasmid, and a transient mutator state. The implications of these various phenomena for adaptive evolution in microorganisms are discussed. BioEssays 22:1067–1074, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

The relationship of embryonal carcinoma (EC) cells, the stem cells of germ cell‐ or embryo‐derived teratocarcinoma tumors, to early embryonic cells came under intense scrutiny in the early 1970s when mouse chimeras were produced between EC cells and embryos. These chimeras raised tantalizing possibilities and high hopes for different areas of research. The normalization of EC cells by the embryo lent validity to their use as in vitro models for embryogenesis and indicated that they might reveal information about the relationship (...) between malignancy and differentiation. Chimeras also showed the way for the potential introduction of genes, selected in EC cells in vitro, into the germ line of mice. Although EC cells provided material for the elucidation of early embryonic events and stimulated many studies of early molecular differentiation, after years of intense scrutiny, they fell short as the means of genetic manipulation of the germ line, although arguably they pointed the way to the development of embryonic stem (ES) cells that eventually fulfilled this goal. (shrink)

Rather than using literary texts to evidence an analytic argument, within this piece we read Julia McNair Wright's (US, 1840?1902), Sidonie-Gabrielle Colette's (France, 1873?1954), and Willa Cather's (US, 1873?1947) texts through theoretical lenses that expose their educational meaning and value and that create conversation among them concerning girls? and women's educations. While we do not claim that one can generalize these women's works and lessons to every life, we contend that these women and the literary products they created offer girls (...) and women powerful lessons about resistance, subversion, and nurturing one's intellect, lessons that in some ways transcend class and race in particular. First, we define and explain Bruner's concept of the more using Rosenblatt, Gallagher, and Gardner's theories and findings to illuminate his concept. Next, we identify and examine three themes that emerge across these authors? texts?subverting through the everyday, becoming one's own steward, and moving from survival to self-actualization. Establishing these themes first in Wright's texts, we then use them to frame Colette's and Cather's fiction and support these themes by focusing on one lesson that emerges from each author's work(s). Finally, we ask what one might learn about educating girls and women from these texts and others whose educative meaning and value remain hidden. (shrink)

This article analyses the accusation of nihilism that F. H. Jacobi made against Fichte in a letter of mars. 1799, imputation that lays on the personal conception ofJacobi about the reason as a negative capacity which only can destroy its objects. The letter in question implicates two different types of nihilism: a)The cosmological one, accepted by Fichte and named acosmism by him. It is only a reformulation of the sensible world from practical principIes, but doesn't suppose an annihilation or scorn (...) of this world. Qn the contrary, the religious view, for example, shows the world as a manifestation of godlite and, hased on moral exigencies, doesn~t admit the existence of death. Of course, the immortality isn't for a particular soul but for the order of moral actions (= God). b) The radical one, which doesn't exist in Fichte and lays on a bad interpretation of bis intellectual intuition assumed from a point of view next to Schelling. (shrink)

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

Eye movements during false-belief tasks can reveal an individual's capacity to implicitly monitor others' mental states (theory of mind - ToM). It has been suggested, based on the results of a single-trial-experiment, that this ability is impaired in those with a high-functioning autism spectrum disorder (ASD), despite neurotypical-like performance on explicit ToM measures. However, given there are known attention differences and visual hypersensitivities in ASD it is important to establish whether such impairments are evident over time. In addition, investigating implicit (...) ToM using a repeated trial approach allows an assessment of whether learning processes can reduce the ASD impairment in this ability, as is the case with explicit ToM. Here we investigated the temporal profile of implicit ToM in individuals with ASD and a control group. Despite similar performance on explicit ToM measures, ASD-diagnosed individuals showed no evidence of implicit false-belief tracking even over a one-hour period and many trials, whereas control participants did. These findings demonstrate that the systems involved in implicit and explicit ToM are distinct and hint that impaired implicit false-belief tracking may play an important role in ASD. Further, they indicate that learning processes do not alleviate this impairment across the presentation of multiple trials. (shrink)

Using content analysis, the authors categorize all Social Issues in Management (SIM) Division papers and abstracts (636) from 1972 through 1996 by subject matter and methodology. Showing the development of the field over time, the authors integrate their findings into previous SIM frameworks. Adaptation to the changing business environment is apparent in the subject matter. Although terminology and context (such as employee rights concerning electronic mail) may have changed, the topics are similar. Nevertheless, evolution in the SIM field is apparent. (...) Methodology has become much more sophisticated as researchers use existing and newly created databases and more rigorous techniques-such as event studies and meta-analysis. (shrink)

Hastings Center Report, Volume 52, Issue S1, Page S83-S88, March‐April 2022.

To find more information about Rowman and Littlefield titles, please visit www.rowmanlittlefield.com.

Local health officials are called upon every day to implement the programs, enforce the regulations, and take the actions that protect the health of the citizens in their districts. These responsibilities and duties are created and regulated by a complex interplay of federal, state, and local law. Not only is an understanding of these laws necessary to carry out public health activities on a daily basis, but many public health scholars and practitioners also believe that the law can be used (...) as a tool to take proactive steps to improve public health. Unfortunately, many local public health officials do not have access to the legal assistance they need to address the various legal questions that confront them. This deficit makes it harder for them to meet their day-to-day responsibilities and makes it much more difficult for them to use the law proactively as a method to improve public health in their communities. In addition, many of the attorneys who provide legal support to public health departments do not have the time or resources to develop a thorough and up-to-date understanding of public health law. This paper examines the experience of a number of local health offices in obtaining legal advice and of attorneys who provide legal advice and assistance to local health departments and assesses different models for organizing and financing the provision of legal services to local public health officials. (shrink)

In the early days of HIV awareness, prior to universal precautions, as a local health officer, I was supervising an openly gay employee. The county executive asked me the HIV status of the employee and threatened my employment if I did not reveal it. I was reluctant to do so, believing it would be an invasion of the employee’s privacy. I contacted the county attorney who advised me that I could reveal the employee’s HIV status to the county executive but (...) he was not willing to put his guidance in writing. Ultimately, I spoke with the employee’s attorney and was given permission to reveal the employee’s HIV status. The experience, however, left a bad taste in my mouth. I felt the county attorney was acting politically in support of the county executive rather than doing what was legally appropriate. He certainly did not act as an advocate for the local health department! (shrink)

O trabalho aborda o cinismo do tipo antropológico autoritário de The Authoritarian Personality em homologia com o fetichismo descrito por Freud. Metapsicologicamente, é trabalhado o problema da síntese do eu e cisão interna a tal instância, bem como a externalização do superego. Sendo este sujeito massificado e esclarecido, a assunção de discursos morais contraditórios na mesma estrutura psíquica possibilitaria a manutenção de preconceito e autoritarismo em ambientes democráticos mediante racionalizações.

Following the guiding thread given by the metaphors used in the title of this paper and which are recurrent in the texts of the philosopher Immanuel Kant himself as well as in most of his commentators’, I selected some themes that the Critique of the Power of Judgment offers us to think about and which remain relevant today: system, critique, reflection, the sublime, and a certain concept of humanity. I have prioritized both Portuguese and Brazilian interpreters without disregarding French authors, (...) everlasting allies, who inspire me since the beginning of my studies. (shrink)

ResumenEl presente trabajo tiene por objetivo mostrar en qué medida el tratamiento nietzscheano en torno al concepto de vida se revela como el espacio adecuado para pensar la lógica de la comunidad y la inmunidad planteada por Roberto Esposito. En vistas a ello hemos de desarrollar la lógica de la comunidad y la inmunidad, para luego mostrar el modo en que la filosofía nietzscheana ofrece en su tematización del fenómeno de lo vital un adecuado trasfondo ontológico para comprender dicha dinámica.Palabras (...) clave Comunidad, inmunidad, vidaAbstract The aim of this paper is to show to what extent the Nietzschean approach to the concept of life offers an adequate field in which we can understand the logic of community and immunity as developed by Roberto Esposito. Therefore, we will analyze the dynamic of the community and the immunity in order to reveal how the phenomenon of life, as theorized by Nietzsche, provides a proper ontological background to understand such dynamic.Keywords Community, immunity, life. (shrink)

Este artigo aborda dois importantes conceitos freudianos que são mobilizados para a explicação do sintoma: o inquietante e o só-depois. Tais noções aparecem como complementares mediante a formação composta do sintoma que se dá entre elementos inconscientes e as vivências posteriores que permitem o retorno do recalcado. Essa composição nos permite tratar a teoria clínica freudiana a partir de um viés temporal, uma vez que a formação do sintoma se dá em etapas descontínuas na trajetória da vida subjetiva. Por isso, (...) nosso artigo discute a passagem dessa descontinuidade – quando o sintoma é sentido como uma repetição inquietante – para a constituição de uma narrativa de vida dotada de destinos pulsionais criativos, nos quais o que se mostrava estranho é assumido como próprio e familiar. Palavras-chave: sintoma; inquietante; estranhamento; só-depois; repetição.: This article discusses two important Freudian concepts that are mobilized for the explanation of the symptom: the uncanny and the afterwardsness. These notions appear together because of the composite formation of symptom that occurs between unconscious elements and aftermost experiences that allow the return of the repressed. This composition helps us in our goal to treat Freudian clinical theory in a temporal bias, since the formation of the symptom occurs in discontinuous steps along the path of subjective life. So our article discusses the passage of this discontinuity – when the symptom is felt as a uncanny repetition – for the establishment of a narrative of life based on creative instinctual destinations, in which what is showed strange is assumed as own and familiar. Keywords: symptom; uncanny; strangeness; afterwardsness; repetition. (shrink)

Over 200 health journals call on the United Nations, political leaders, and health professionals to recognize that climate change and biodiversity loss are one indivisible crisis and must be tackle...

We present a new road map for research on “How the Brain Got Language” that adopts an EvoDevoSocio perspective and highlights comparative neuroprimatology – the comparative study of brain, behavior and communication in extant monkeys and great apes – as providing a key grounding for hypotheses on the last common ancestor of humans and monkeys and chimpanzees and the processes which guided the evolution LCA-m → LCA-c → protohumans → H. sapiens. Such research constrains and is constrained by analysis of (...) the subsequent, primarily cultural, evolution of H. sapiens which yielded cultures involving the rich use of language. (shrink)

O presente artigo é uma homenagem ao filósofo e professor brasileiro Benedito Nunes. Como foi escrito num período histórico de profunda crise sanitária (pandemia da Covid-19), política (ascensão ao poder do neofascismo no Brasil), social (preponderância do sentimento de ódio entre as classes, as pessoas e até dentro das famílias), econômica (aumento da miséria, reingresso do país no Mapa da Fome), numa palavra: crise humanitária, reuni algumas tentativas de definição de homem, ser humano ou essência humana. Não me restringi às (...) definições estritamente filosóficas, recorri também e, propositalmente, àquelas outras, designadas “poéticas” ou “literárias”. Tentei discorrer e meditar um pouco sobre essas várias definições, inclusive, sobre a noção heideggeriana de Dasein. (shrink)